VigiAccess: Promoting public access to VigiBase

VigiAccess: Promoting public access to VigiBase

Sir, Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. The thalidomide tragedy in the late 1950s and early 1960s provided a strong impetus to initiating an international system of pharmacovigilance. The international drug monitoring system officially started in 1968 with ten countries pooling ADR data from their respective national systems.[1] As of March 2007, th...

Promoting public access to clinical trial protocols: challenges and recommendations

BACKGROUND Recognizing the value of promoting public access to clinical trial protocols, Trials pioneered the way for their publication over a decade ago. However, despite major advances in the public accessibility of information about trial methods and results, protocol sharing remains relatively rare. MAIN BODY Protocol sharing facilitates the critical appraisal of clinical trials and helps...

promoting access to White Rose

23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 Partial EVPI calculations can quantify the value of learning about particular subsets of uncertain parameters in decision models. Published case studies have used different computational approaches. This paper examines the computation of partial EVPI estimates via Monte-Carlo sampling algorithms. Our mathematical definition shows two nest...

promoting access to White Rose

Public access defibrillation: time to access the public.

STUDY OBJECTIVE Public accessible automated external defibrillators (AEDs) are increasingly made available in highly frequented places, allowing coincidental bystanders to defibrillate with minimal delay if necessary. Although the public, as the largest and most readily available group of potential rescuers, is assigned a key role in this concept of "public" access defibrillation, it is unknown...